Opioid action is due to each minimal affinity binding on the guardian compound and better affinity binding of the O-demethylated metabolite M1 to μ-opioid receptors. In animal designs, M1 is as much as 6 occasions more potent than tramadol in manufacturing analgesia and 200 situations additional potent in μ-opioid binding. https://ingmarx988egp6.wikiexcerpt.com/user